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Paul J Dunford Selected Research

1- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazine

1/2017Clinical Development of Histamine H4 Receptor Antagonists.
6/2010Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines.
4/2010The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation.
10/2005Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.
4/2004A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.

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Paul J Dunford Research Topics

Disease

9Inflammation (Inflammations)
01/2017 - 04/2004
7Asthma (Bronchial Asthma)
01/2017 - 01/2007
5Pruritus (Itching)
01/2017 - 01/2007
4Colitis
01/2019 - 10/2005
3Atopic Dermatitis (Atopic Eczema)
01/2017 - 04/2010
3Hypersensitivity (Allergy)
01/2010 - 01/2007
2Rheumatoid Arthritis
04/2019 - 01/2017
2Agranulocytosis (Granulocytopenia)
01/2017 - 03/2014
2Edema (Dropsy)
04/2010 - 06/2007
2Peritonitis
06/2007 - 04/2004
1Crohn Disease (Crohn's Disease)
01/2019
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2019
1Psoriasis (Pustulosis Palmaris et Plantaris)
01/2017
1Nausea
07/2014
1Headache (Headaches)
07/2014
1Dermatitis
03/2014
1Experimental Arthritis
03/2014
1Arthritis (Polyarthritis)
03/2014
1Disease Progression
03/2014
1Hyperplasia
06/2010
1Airway Remodeling
06/2010
1Pneumonia (Pneumonitis)
05/2010
1Melanoma (Melanoma, Malignant)
03/2008
1Otitis
06/2007
1Immune System Diseases (Immune Disorders)
03/2007
1Animal Disease Models
03/2007
1Necrosis
10/2005

Drug/Important Bio-Agent (IBA)

9Histamine (Histamine Dihydrochloride)FDA Link
04/2019 - 10/2005
9Histamine H4 ReceptorsIBA
07/2014 - 10/2005
51- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazineIBA
01/2017 - 04/2004
34- (3- aminopyrrolidin- 1- yl)- 6- isopropylpyrimidin- 2- ylamineIBA
01/2017 - 03/2014
3Histamine Antagonists (Antihistamines)IBA
01/2010 - 01/2007
2toreforantIBA
04/2019 - 01/2017
2Pharmaceutical PreparationsIBA
01/2017 - 03/2014
2CollagenIBA
03/2014 - 06/2010
2Histamine Receptors (Histamine Receptor)IBA
01/2010 - 01/2007
2Histamine H1 Receptors (Histamine H1 Receptor)IBA
01/2010 - 01/2008
2ZymosanIBA
06/2007 - 04/2004
1Methotrexate (Mexate)FDA LinkGeneric
04/2019
1Macrophage Colony-Stimulating Factor Receptor (Receptor, Macrophage Colony Stimulating Factor)IBA
01/2019
1JNJ-40346527IBA
01/2019
1Macrophage Colony-Stimulating FactorIBA
01/2019
1Phosphotransferases (Kinase)IBA
01/2019
1Cetirizine (Zyrtec)FDA LinkGeneric
07/2014
1Interleukin-17 (Interleukin 17)IBA
03/2014
1CytokinesIBA
06/2010
1Leukotriene A4IBA
05/2010
1Leukotriene B4IBA
05/2010
1HydrolasesIBA
05/2010
1Fluorescein-5-isothiocyanate (FITC)IBA
04/2010
1Biomarkers (Surrogate Marker)IBA
03/2008
1Mitogen-Activated Protein Kinase 3IBA
03/2008
1Interleukin-8 (Interleukin 8)IBA
03/2008
1AgarIBA
03/2008
1piperidineIBA
06/2007
1Carboxylic AcidsIBA
06/2007
1Arachidonic Acid (Vitamin F)IBA
06/2007
11- (4- (benzothiazol- 2- yloxy)benzyl)piperidine- 4- carboxylic acidIBA
06/2007
1cysteinyl-leukotrieneIBA
06/2007
1zileuton (Zyflo)FDA Link
06/2007
1LipoxinsIBA
06/2007
1HaptensIBA
03/2007
1Peroxidase (Myeloperoxidase)IBA
10/2005
1JNJ 10191584IBA
10/2005
1AcidsIBA
10/2005
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2005

Therapy/Procedure

2Therapeutics
01/2019 - 06/2010